Understanding how the body's internal clock regulates processes
Inter- and intracellular mechanisms of circadian regulation
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-10813042
This study is looking at how our body's internal clock works by using a plant called Arabidopsis to see how certain proteins move around in cells and how changes to these proteins affect their job, helping us understand how our natural rhythms keep everything in sync.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10813042 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind circadian rhythms, which are the body's natural timing systems that influence various physiological and metabolic processes throughout the day. By using the model plant Arabidopsis, researchers will explore how proteins involved in the circadian clock are transported within cells and how their modifications affect their function. The study employs advanced genetic, genomic, and imaging techniques to observe these processes at a single-cell level, aiming to uncover the intricate relationships that maintain the circadian oscillator's function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that may be influenced by circadian rhythms, such as certain cancers or metabolic disorders.
Not a fit: Patients who do not have conditions related to circadian rhythms or metabolic processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how circadian rhythms affect health and disease, potentially improving treatment strategies for conditions influenced by these biological clocks.
How similar studies have performed: While the specific application of single-cell imaging in circadian studies is novel, research on circadian rhythms has shown significant success in understanding their impact on health.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOMERS, DAVID E — OHIO STATE UNIVERSITY
- Study coordinator: SOMERS, DAVID E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer