Understanding how the body's internal clock affects colorectal cancer in young adults
Circadian Clock and Myc-dependent Regulation of Cellular Transformation
This study is looking at why more young adults between 15 and 40 are getting colorectal cancer, focusing on how our body clocks and certain genes might play a role, and it aims to find out if what and when we eat could be linked to this increase.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11010358 on NIH RePORTER |
What this research studies
This research investigates the rising incidence of colorectal cancer (CRC) in young adults aged 15-40, focusing on the role of circadian rhythms and genetic mutations. The study aims to explore how disruptions in the body's internal clock may contribute to the development of early-onset CRC, particularly in individuals with specific genetic mutations like Apc. By examining the relationship between diet, timing of food intake, and circadian clock function, the research seeks to uncover potential underlying causes of this alarming trend. Patients may be involved in assessments that evaluate their dietary habits and genetic profiles to better understand these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults aged 15-40, particularly those with a family history of colorectal cancer or known genetic mutations.
Not a fit: Patients over the age of 40 or those without risk factors for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies and treatments for colorectal cancer in young adults.
How similar studies have performed: Previous research has indicated a link between circadian rhythms and cancer development, suggesting that this approach may yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Masri, Selma — University of California-Irvine
- Study coordinator: Masri, Selma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.