Understanding how the body's immune signals work
Identification of novel type III IFN regulatory pathways
This research explores how certain immune signals, called interferons, balance protecting our cells from harm and causing inflammation, especially in areas like the skin and gut.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11144955 on NIH RePORTER |
What this research studies
Our bodies use special signals called interferons to fight off infections and respond to stress, but sometimes these signals can cause too much inflammation and damage. This project focuses on a specific type of interferon, IFNλ, which is important in barrier tissues like the skin and gut lining. We want to understand how IFNλ helps protect these tissues without causing harmful inflammation. By looking at how cells communicate and respond to stress, we hope to learn why these signals sometimes go wrong.
Who could benefit from this research
Good fit: Patients with conditions involving uncontrolled inflammation, viral infections, or tissue damage where interferon responses play a role could potentially benefit from future treatments developed from this foundational knowledge.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to control inflammation and protect tissues from damage in conditions involving viral infections or cellular stress.
How similar studies have performed: This project builds upon previous work that has identified how different interferon signals can lead to harmful responses, and it aims to explore new aspects of IFNλ functions.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Forero, Adriana — Ohio State University
- Study coordinator: Forero, Adriana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.