Understanding how the body responds to influenza virus
Dynamic regulatory network models of human response to influenza virus
This study is looking at how our immune system responds to the flu virus to understand why some people get really sick while others don’t feel much at all, and it aims to find new ways to help prevent or lessen flu symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10842339 on NIH RePORTER |
What this research studies
This research aims to create mathematical models that explain how the human immune system reacts to the influenza virus. By studying the interactions between the virus and the host's genetic makeup, the researchers hope to identify why some individuals experience severe symptoms while others remain asymptomatic. The project will utilize advanced techniques to analyze human lung cells and their responses to the virus, focusing on the genetic factors that influence these responses. Ultimately, the goal is to uncover potential therapeutic targets that could help prevent or reduce the severity of influenza infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with varying genetic backgrounds who are at risk of influenza infection.
Not a fit: Patients who have already been vaccinated against influenza or those with pre-existing severe respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response to influenza, potentially saving lives.
How similar studies have performed: Previous research has shown promise in understanding immune responses to viral infections using similar modeling approaches, indicating potential for success in this area.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Marazzi, Ivan — University of California-Irvine
- Study coordinator: Marazzi, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.