Understanding how the body resolves infectious inflammation
Evaluating Resolution Mechanisms for Infectious Inflammation
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11051894
This study is looking at how our bodies naturally fight inflammation from infections like sepsis, to find new ways to help people heal better and faster.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11051894 on ClinicalTrials.gov |
What this research studies
This research investigates the body's natural mechanisms for resolving inflammation caused by infections, particularly focusing on sepsis, a severe condition that can arise from trauma or infections. The study aims to identify and understand specialized pro-resolving mediators (SPM), which are molecules that help the body heal and reduce inflammation. By examining these mediators in both animal models and human tissues, the research seeks to uncover how inflammation resolution can be improved, potentially leading to new treatments for patients suffering from sepsis and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced sepsis or are at high risk for developing severe infections.
Not a fit: Patients with chronic inflammatory conditions unrelated to infectious inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the body's ability to resolve infections and reduce the risk of sepsis-related complications.
How similar studies have performed: Previous research has shown promise in understanding the role of specialized pro-resolving mediators in inflammation, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SERHAN, CHARLES NICHOLAS — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: SERHAN, CHARLES NICHOLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.