Understanding how the body regulates manganese levels
Molecular mechanism underlying the regulation of manganese homeostasis
This study is looking at how a protein called ZIP14 helps keep manganese levels just right in the body, which is important for your health, and it’s for anyone interested in understanding how manganese balance affects growth and brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10806952 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, ZIP14, in managing manganese levels in the body. Manganese is crucial for various bodily functions, but both too little and too much can lead to serious health issues, including growth problems and neurological disorders. The study will use cell assays and genetically modified mice to explore how ZIP14 helps transport manganese and maintain its balance in the body. By understanding these mechanisms, the research aims to shed light on conditions related to manganese imbalance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known manganese metabolism disorders or related health issues.
Not a fit: Patients without any manganese-related health conditions or those not experiencing symptoms related to manganese imbalance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for conditions caused by manganese deficiency or overload.
How similar studies have performed: While the specific focus on ZIP14 is novel, research on manganese metabolism has shown promising results in understanding related health conditions.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Zhao, Ningning — University of Arizona
- Study coordinator: Zhao, Ningning
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.