Understanding how the body reacts to long-term effects after COVID-19 infection
Host cellular network governing the development of post SARS-CoV-2 tissue sequelae
This study is looking at how certain immune cells in your body interact after having COVID-19, which might help explain why some people experience ongoing health problems, and it hopes to find new ways to help those dealing with these long-term effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11044253 on NIH RePORTER |
What this research studies
This research investigates the cellular interactions that contribute to long-term health issues following COVID-19 infection, known as post-acute sequelae of SARS-CoV-2 infection (PASC). By analyzing single cell RNA sequencing data, the study focuses on how immune cells, particularly T cells and macrophages, interact and the role of the cytokine IFN-γ in these processes. The researchers aim to uncover the mechanisms behind chronic respiratory issues and explore potential treatments that could alleviate these long-term effects. Patients may benefit from insights that could lead to new therapeutic strategies for managing post-COVID conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced long-term symptoms following COVID-19 infection.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those without any post-viral symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help alleviate chronic health issues experienced by COVID-19 survivors.
How similar studies have performed: Other research has shown promise in understanding post-viral syndromes, but this specific approach focusing on the IFN-γ-STAT1 pathway is relatively novel.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Sun, Jie — University of Virginia
- Study coordinator: Sun, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.