Understanding how the body reacts to infections and causes sickness symptoms
Characterization of the molecular and cellular mechanisms underlying the sickness symptoms
['FUNDING_OTHER'] · UNIVERSITY OF UTAH · NIH-10995281
This study is looking at how certain brain cells help cause symptoms like fever and loss of appetite when you're sick, to better understand how your body reacts to infections and how we might help manage those symptoms.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10995281 on ClinicalTrials.gov |
What this research studies
This research investigates the biological mechanisms that lead to sickness symptoms during acute infections, such as fever and loss of appetite. By studying specific neurons in the brain that respond to immune signals, the research aims to uncover how these signals affect behavior and physiology. The approach involves advanced techniques to manipulate these neurons and observe their effects on sickness symptoms. This could provide insights into how the body naturally responds to infections and how these responses can be managed.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing acute infections that lead to pronounced sickness symptoms.
Not a fit: Patients with chronic illnesses or those not experiencing acute infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing sickness symptoms during infections, improving patient comfort and recovery.
How similar studies have performed: Other research has shown success in understanding immune responses and their effects on behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OSTERHOUT, JESSICA ALLISON — UNIVERSITY OF UTAH
- Study coordinator: OSTERHOUT, JESSICA ALLISON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection, Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease