Understanding how the body produces allergy-related antibodies in response to airborne allergens
Official title: Regulation of IgE production during aeroallergen sensitization
Funded at University of California, San Francisco · NIH-11094709 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs make IgE antibodies, which play a big role in allergies and asthma, to help us understand what happens in the body when people are exposed to allergens.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 24, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $205,000 |
| NIH project number | 5R21AI178523-02 |
| Project ID | NIH-11094709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with asthma or allergic conditions, particularly those who experience symptoms triggered by airborne allergens.
✕Less likely to help
Patients who do not have asthma or any form of allergic response to airborne substances may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the production of IgE antibodies, which are crucial in allergic responses, particularly in asthma. By using advanced techniques like flow cytometry and microscopy, the study aims to identify rare IgE-expressing cells in the respiratory tract after exposure to airborne allergens. The research will utilize mouse models to closely examine the cellular responses involved in allergic sensitization. This approach could provide insights into how allergic inflammation develops in asthma patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating asthma and other allergic diseases.
How similar studies have gone: Previous research has shown promising results in understanding allergic responses through similar methodologies, indicating potential for success in this area.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Allen, Christopher David Caballero — University of California, San Francisco
- Study coordinator: Allen, Christopher David Caballero
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.