Understanding how the body processes and eliminates toxins
Official title: Mapping the Glucuronidome
Funded at Pennsylvania State University, the · NIH-10874401 · Data updated 2026-11-12
This study is looking at how our bodies get rid of harmful substances and how things like our diet and gut bacteria can change this process, which might help us understand how we react to medications and toxins better, especially for people dealing with chronic diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $37,018 |
| NIH project number | 5F31DK134090-02 |
| Project ID | NIH-10874401 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic diseases or those experiencing adverse reactions to medications.
✕Less likely to help
Patients who do not have chronic diseases or are not taking medications that could be affected by glucuronidation may not benefit from this research.
What this research studies
This research investigates how the body detoxifies harmful compounds through a process called glucuronidation, which involves adding glucuronic acid to these compounds. It explores how dietary factors and gut bacteria influence this detoxification process, potentially affecting the metabolism of medications and the body's response to toxins. By utilizing advanced techniques like mass spectrometry and genomic sequencing, the research aims to map the interactions between the body, its metabolites, and the microbiome. This comprehensive approach could lead to better understanding and management of chronic diseases and drug reactions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic diseases and reduced adverse reactions to medications.
How similar studies have gone: Previous research has shown promising results in understanding the role of the microbiome in drug metabolism, indicating that this approach could yield significant insights.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Boyle, Nina — Pennsylvania State University, the
- Study coordinator: Boyle, Nina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.