Understanding How the Body Manages Sugar and Energy
Gluconeogenesis and Glycogenolysis - Role and Regulation
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-11187131
This research helps us understand how a diet high in fat and sugar can affect how your body controls blood sugar, especially in the liver.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-11187131 on ClinicalTrials.gov |
What this research studies
Our bodies normally switch between making and taking up sugar in the liver, which is key for keeping blood sugar levels healthy. When people eat a diet high in fat and fructose, this process can get out of balance, leading to problems like insulin resistance. This project uses a special dog model to explore how these diets disrupt the liver's ability to manage sugar. We are also looking at how different ways of giving insulin might affect the liver compared to how the body naturally produces it.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with adult-onset diabetes mellitus in the future.
Not a fit: Patients not affected by diet-induced glucose intolerance or those with other forms of diabetes may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: This work could lead to a better understanding of how diet contributes to diabetes and help develop new ways to manage blood sugar for people with the condition.
How similar studies have performed: This project builds upon recent findings by the researchers, suggesting a foundation of prior successful work in this area.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EDGERTON, DALE S — VANDERBILT UNIVERSITY
- Study coordinator: EDGERTON, DALE S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus