Understanding how the body manages iron through protein quality control
Novel role of endoplasmic reticulum-associated degradation in iron metabolism
This study is looking at how a process in our cells helps control iron levels in the body by getting rid of faulty proteins, which could lead to better understanding and new treatments for people with aceruloplasminemia, a condition where iron builds up too much.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10996171 on NIH RePORTER |
What this research studies
This research investigates the role of a cellular process called endoplasmic reticulum-associated degradation (ERAD) in managing iron levels in the body. It focuses on a specific protein complex that helps eliminate misfolded proteins, which can disrupt iron metabolism. By studying how this process affects a protein known as ceruloplasmin, which is crucial for iron regulation, the research aims to uncover new insights into conditions like aceruloplasminemia, where iron accumulates abnormally in the body. Patients may benefit from a better understanding of their condition and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with aceruloplasminemia or other related iron metabolism disorders.
Not a fit: Patients without any iron metabolism disorders or related genetic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with iron metabolism disorders.
How similar studies have performed: Previous research has shown promising results in understanding protein quality control mechanisms, suggesting potential for success in this area.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Sun, Shengyi — University of Virginia
- Study coordinator: Sun, Shengyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.