Understanding how the body makes Coenzyme A and its role in metabolism
Official title: Regulation and Requirements for Coenzyme A Biosynthesis
Funded at Beth Israel Deaconess Medical Center · NIH-11173920 · Data updated 2026-11-12
This study is looking at how your body makes a key substance called Coenzyme A, which is important for keeping your liver and kidneys healthy, and it hopes to find out how problems with this process might be linked to conditions like fatty liver disease and chronic kidney disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $675,660 |
| NIH project number | 1R56DK140239-01 |
| Project ID | NIH-11173920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from metabolic dysfunction-associated fatty liver disease or chronic kidney disease.
✕Less likely to help
Patients with conditions unrelated to lipid metabolism or CoA synthesis may not benefit from this research.
What this research studies
This research investigates the processes that regulate the production of Coenzyme A (CoA), a vital cofactor for various metabolic functions, particularly in the liver and kidneys. It aims to uncover how CoA synthesis is coordinated with the body's metabolic needs and how disruptions in this process may contribute to diseases like fatty liver disease and chronic kidney disease. The study will explore the role of specific enzymes and signaling pathways that influence CoA levels, potentially leading to new insights into metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for metabolic disorders related to CoA dysregulation, benefiting millions of patients.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways related to CoA, indicating potential for success in this area.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Dibble, Christian — Beth Israel Deaconess Medical Center
- Study coordinator: Dibble, Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.