Understanding how the body makes cholesterol and its effects on intestinal health
Physiological Dissection of the Mevalonate Pathway
This study is looking at how cholesterol production affects the cells in your intestines and how your body manages cholesterol, which could help us understand more about keeping your gut healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11049649 on NIH RePORTER |
What this research studies
This research investigates the mevalonate pathway, which is crucial for synthesizing cholesterol and other important molecules in the body. By using genetically engineered mouse models and human organoids, the study aims to uncover how cholesterol production affects intestinal stem cells and their ability to regenerate the intestinal lining. The research will also explore how cholesterol absorption and excretion are regulated in the intestine, which plays a vital role in maintaining overall health. Patients may benefit from insights gained about cholesterol metabolism and its implications for intestinal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cholesterol metabolism or intestinal disorders.
Not a fit: Patients who do not have issues related to cholesterol metabolism or intestinal health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions related to cholesterol metabolism and intestinal health.
How similar studies have performed: Previous research has shown success in understanding cholesterol metabolism, but this specific investigation into the mevalonate pathway in the intestine is relatively novel.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lagor, William Raymond — Baylor College of Medicine
- Study coordinator: Lagor, William Raymond
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.