Understanding how the body heals after liver injury from reduced blood flow
Inflammation Resolution in Liver Ischemia-Reperfusion Injury
This research aims to understand how the body's natural healing process, called inflammation resolution, works after liver injury caused by temporary lack of blood flow, which often happens during liver surgery or transplantation.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11176143 on NIH RePORTER |
What this research studies
When the liver experiences a temporary lack of blood flow, such as during surgery or a transplant, it can lead to injury and inflammation. Our bodies have a natural way to resolve this inflammation and heal, but this process isn't fully understood in liver injuries. This project looks at how the immune system, particularly certain cells in the liver, helps to calm inflammation and restore the liver to health. We want to find out if improving this healing process could help prevent complications like transplant rejection.
Who could benefit from this research
Good fit: This foundational research is relevant for adult patients undergoing liver tumor resection or liver transplantation who are at risk for ischemia-reperfusion injury.
Not a fit: Patients without liver ischemia-reperfusion injury or those not undergoing liver surgery or transplantation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to help patients recover better after liver surgery or transplantation by promoting the body's natural healing processes.
How similar studies have performed: While the concept of inflammation resolution is recognized, its specific mechanisms in human liver ischemia-reperfusion injury and its link to transplant rejection are not well-defined, making this a novel area of focus.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Zhai, Yuan — University of California Los Angeles
- Study coordinator: Zhai, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.