Understanding how the body handles medicines to prevent side effects
Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors
This research aims to understand how certain proteins in the liver control how medicines move through your body, helping to prevent unwanted side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11117159 on NIH RePORTER |
What this research studies
Our bodies have special proteins in the liver, called OATP1B1 and OATP1B3, that help move many important medicines, like cholesterol-lowering drugs and cancer treatments, from your blood into the liver. Sometimes, these proteins don't work correctly, leading to serious side effects or drug interactions, such as muscle damage from statins. We want to discover how a process called lysine acetylation controls these proteins. By understanding this process, we hope to better predict and prevent harmful drug interactions and side effects.
Who could benefit from this research
Good fit: This foundational research is for future patients who take medications that are processed by the liver, especially those prone to drug interactions or side effects.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not receive direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to safer use of many medications by helping doctors predict and avoid severe side effects and drug interactions.
How similar studies have performed: While the general role of these proteins is known, this specific approach of investigating lysine acetylation as a regulator of OATP1B1/3 function is novel and has not been widely explored.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Yue, Wei — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Yue, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.