Understanding how the body gets rid of manganese and its effects on brain health
Role and mechanisms of excretion in manganese neurotoxicity
This study is looking at how the body gets rid of manganese and how that might help protect the brain from damage, especially for people with liver disease, to find better ways to keep their neurological health in check.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-10875526 on NIH RePORTER |
What this research studies
This research investigates the role of manganese excretion in preventing neurotoxicity, particularly in individuals with liver disease. It focuses on how manganese is transported and excreted by the liver and intestines, and how genetic variations may affect this process. By studying specific transporters involved in manganese excretion, the research aims to clarify the relationship between manganese levels in the body and neurological health. This could lead to better understanding and potential interventions for manganese-related neurotoxicity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with elevated manganese levels, particularly those with liver disease or genetic predispositions affecting manganese excretion.
Not a fit: Patients without any issues related to manganese metabolism or neurotoxicity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating manganese-induced neurotoxicity.
How similar studies have performed: While the direct mechanisms of manganese excretion are not widely studied, related research has shown that understanding metal transport can lead to significant insights in neurotoxicity.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Mukhopadhyay, Somshuvra — University of Texas at Austin
- Study coordinator: Mukhopadhyay, Somshuvra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.