Understanding how the body forms bone in the wrong places after injuries
The Role of Extracellular Matrix Dysregulation in Heterotopic Ossification
This study is looking into why some veterans develop extra bone growth in their muscles and tissues after injuries or surgeries, with the goal of finding better ways to prevent or treat this condition and help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10911076 on NIH RePORTER |
What this research studies
This research investigates heterotopic ossification (HO), a condition where bone forms in soft tissues following musculoskeletal injuries, particularly in veterans. The study aims to uncover the molecular mechanisms behind this abnormal bone growth, which can occur after traumatic injuries or surgeries like joint replacements and amputations. By understanding these processes, the research seeks to develop targeted therapies to prevent or treat HO, ultimately improving patient outcomes and quality of life. The focus is on veterans, who are at a higher risk for HO due to the nature of their injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who have experienced musculoskeletal injuries or surgeries that may lead to heterotopic ossification.
Not a fit: Patients who have not experienced musculoskeletal injuries or surgeries related to bone growth issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent painful and debilitating bone growth in soft tissues, enhancing mobility and quality of life for affected patients.
How similar studies have performed: While the mechanisms of heterotopic ossification are not fully understood, similar research has shown promise in identifying pathways that could be targeted for treatment.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Peck, Sun H — Veterans Health Administration
- Study coordinator: Peck, Sun H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.