Understanding how the body fights the Seoul Hantavirus
Role of Type I IFN Signaling in Seoul Orthohantavirus Pathogenesis
This research looks at how the body's immune system responds to the Seoul hantavirus, which causes a severe illness called hemorrhagic fever with renal syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-11121018 on NIH RePORTER |
What this research studies
Hantaviruses, like the Seoul virus, cause a serious condition called hemorrhagic fever with renal syndrome, mainly in Asia. This virus attacks blood vessel cells, leading to leaky blood vessels and kidney problems, and currently, there are no specific treatments. We want to understand why the body's natural defense system, called Type I interferon, doesn't always stop the Seoul virus effectively. By comparing how human and rat cells react to the virus, we hope to uncover new ways the virus causes disease and how our bodies try to fight it.
Who could benefit from this research
Good fit: This foundational research is for individuals affected by or at risk of hemorrhagic fever with renal syndrome caused by the Seoul hantavirus.
Not a fit: Patients with conditions unrelated to hantavirus infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or ways to prevent the severe symptoms of hemorrhagic fever with renal syndrome caused by the Seoul hantavirus.
How similar studies have performed: This research builds on previous findings about how the immune system fights other hantaviruses, but explores new aspects of how the Seoul hantavirus evades these defenses.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Kell, Alison — University of New Mexico Health Scis Ctr
- Study coordinator: Kell, Alison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.