Understanding how the body fights Shigella flexneri infection
Official title: Host defense against Shigella flexneri
Funded at International Ctr/diarrhoeal Dis Res · NIH-10601092 · Data updated 2026-11-12
This study is looking at how the body reacts to infections from a germ called Shigella flexneri, which causes bad diarrhea, especially in kids, to help find new ways to boost our natural defenses and improve treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | International Ctr/diarrhoeal Dis Res NIH-funded |
| Lab location | 1 site (Dhaka, Bangladesh) |
| Project start | July 27, 2019 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $74,649 |
| NIH project number | 5K43TW011441-05 |
| Project ID | NIH-10601092 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under the age of 11 who have been diagnosed with Shigella flexneri infection.
✕Less likely to help
Patients who are not infected with Shigella flexneri or those over the age of 21 may not receive any benefit from this research.
What this research studies
This research aims to explore how the human body responds to infections caused by Shigella flexneri, a bacterium responsible for severe diarrhea, particularly in children. By comparing tissue samples from patients during acute illness and recovery, the study seeks to identify specific genes and cellular processes that play a role in the infection and recovery. The findings could lead to the development of new treatments that enhance the body's natural defenses against this pathogen.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery from Shigella infections, particularly benefiting vulnerable populations such as young children.
How similar studies have gone: Previous research has shown promise in understanding host-pathogen interactions, but this specific approach to studying Shigella flexneri is relatively novel.
Where this research is happening
-
International Ctr/diarrhoeal Dis Res
Dhaka, Bangladesh Active
Researchers
- Principal investigator: Noor, Zannatun — International Ctr/diarrhoeal Dis Res
- Study coordinator: Noor, Zannatun
Related research
Other NIH-funded projects on the same topics.
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Bangladesh center studies how cleaner cooking and air reduce health problems
A large study in Bangladesh is looking at how reducing household air pollution from cooking and other burning sources may improve heart and immune health in people of all ages.
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Improving public health in Bangladesh by studying emerging infections.
This study is all about finding and fighting new infections that could harm people's health in Bangladesh by looking at how humans, animals, and the environment are all connected, and it aims to create better ways to diagnose and treat these illnesses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.