Understanding how the body fights Shigella flexneri infection
Host defense against Shigella flexneri
This study is looking at how the body reacts to infections from a germ called Shigella flexneri, which causes bad diarrhea, especially in kids, to help find new ways to boost our natural defenses and improve treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | International Ctr/diarrhoeal Dis Res NIH-funded |
| Lab location | 1 site (Dhaka, Bangladesh) |
| Project ID | NIH-10601092 on NIH RePORTER |
What this research studies
This research aims to explore how the human body responds to infections caused by Shigella flexneri, a bacterium responsible for severe diarrhea, particularly in children. By comparing tissue samples from patients during acute illness and recovery, the study seeks to identify specific genes and cellular processes that play a role in the infection and recovery. The findings could lead to the development of new treatments that enhance the body's natural defenses against this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 11 who have been diagnosed with Shigella flexneri infection.
Not a fit: Patients who are not infected with Shigella flexneri or those over the age of 21 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery from Shigella infections, particularly benefiting vulnerable populations such as young children.
How similar studies have performed: Previous research has shown promise in understanding host-pathogen interactions, but this specific approach to studying Shigella flexneri is relatively novel.
Where this research is happening
Dhaka, Bangladesh
- International Ctr/diarrhoeal Dis Res — Dhaka, Bangladesh (Active)
Researchers
- Principal investigator: Noor, Zannatun — International Ctr/diarrhoeal Dis Res
- Study coordinator: Noor, Zannatun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.