Understanding how the body fights Salmonella and Shigella in children and adults
Mechanisms of Induction and Maintenance of Systemic and Gut Mucosal T Cell Immunity to Salmonella and Shigella Following Infection and Vaccination in Children and Adults
This research aims to understand how our immune system protects us from serious infections like Salmonella and Shigella, especially in children and adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11173632 on NIH RePORTER |
What this research studies
We are looking closely at how the body's immune cells, called T cells, respond to Salmonella and Shigella bacteria, both after natural infection and after vaccination. Our goal is to discover the specific ways these immune responses are created and how they last over time, particularly in the gut. We will use special samples from previous clinical studies involving children and adults to uncover these important details. This work will help us learn more about the body's protective immunity against these common and dangerous infections.
Who could benefit from this research
Good fit: This research focuses on understanding immune responses in children (0-11 years old) and adults (21+ years old) who have been exposed to Salmonella or Shigella or received related vaccines.
Not a fit: Patients not affected by Salmonella or Shigella infections, or those outside the age groups of focus for this research, may not directly benefit from this particular study.
Why it matters
Potential benefit: If successful, this work could lead to the development of more effective and long-lasting vaccines for Salmonella and Shigella, especially for vulnerable populations like children.
How similar studies have performed: While there has been progress in understanding T cell immunity to these bacteria, this work addresses crucial gaps in knowledge regarding the specific mechanisms of immune response induction and persistence.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Sztein, Marcelo B. — University of Maryland Baltimore
- Study coordinator: Sztein, Marcelo B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.