Understanding how the body clears Streptococcus pneumoniae from the middle ear in young children
Host factors influencing early clearance of Streptococcus pneumoniae from the middle ear following invasion from the nasopharynx
This study looks at how quickly young children's bodies can get rid of a common ear infection-causing bacteria and how viral infections might make it harder, with the goal of finding better treatments for kids with ear infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10768626 on NIH RePORTER |
What this research studies
This research investigates the factors that influence how quickly the body can eliminate the bacteria Streptococcus pneumoniae from the middle ear, particularly in young children. Using a new mouse model that mimics the conditions in children, the study explores how viral infections can increase the risk of bacterial infections in the ear. By examining the immune response, specifically the role of type I interferons and anti-inflammatory cytokines, the research aims to uncover new therapeutic strategies to improve outcomes for children suffering from ear infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are young children aged 0-11 years who are experiencing or are at risk for bacterial otitis media.
Not a fit: Patients who are older than 11 years or those without a history of ear infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bacterial ear infections in children, potentially reducing hospital visits and preventing hearing loss.
How similar studies have performed: Other research has shown promise in understanding the immune response to bacterial infections, but this specific approach using a new mouse model is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Clark, Sarah E — University of Colorado Denver
- Study coordinator: Clark, Sarah E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.