Understanding how the body breaks down excess mucus in airway diseases
Autophagy-mediated mucin degradation is necessary for resolution of mucous metaplasia
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11061809
This study is looking at how a natural process in our cells, called autophagy, can help reduce the extra mucus produced in conditions like asthma and COPD, with the hope of finding new ways to improve breathing for patients dealing with these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11061809 on ClinicalTrials.gov |
What this research studies
This research investigates the role of autophagy, a cellular recycling process, in resolving mucous metaplasia, a condition where airway cells produce excessive mucus. By studying models of airway diseases like asthma and COPD, the researchers aim to uncover how the degradation of mucin granules can help restore normal airway function. The approach includes using genetic models and cell cultures to observe the effects of autophagy on mucus production and resolution. Patients may benefit from insights that could lead to new treatments for managing mucus-related complications in their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from muco-obstructive airway diseases such as asthma, COPD, cystic fibrosis, or bronchiectasis.
Not a fit: Patients with non-respiratory conditions or those without significant mucus-related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for reducing mucus overproduction in patients with airway diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of autophagy in other diseases, suggesting potential for success in this area as well.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DICKINSON, JOHN DAVID — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: DICKINSON, JOHN DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway Disease