Understanding how the body adapts to the absence of a key thyroid protein.
Official title: Adaptive Response(s) to Complete Thyroglobulin Gene Knockout
Funded at University of Michigan at Ann Arbor · NIH-11040980 · Data updated 2026-11-12
This study looks at what happens when the body can't make thyroid hormones due to a missing gene, helping us understand how this affects growth and health, and it could lead to new treatments for people with thyroid issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,738 |
| NIH project number | 5F30DK139717-02 |
| Project ID | NIH-11040980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital hypothyroidism or those with genetic mutations affecting thyroid hormone production.
✕Less likely to help
Patients without thyroid-related conditions or those who do not have genetic mutations affecting thyroid hormone synthesis may not benefit from this research.
What this research studies
This research investigates the effects of completely knocking out the thyroglobulin gene, which is essential for producing thyroid hormones. It explores how the body responds to the lack of these hormones, which are crucial for growth, metabolism, and overall health. By studying both human cases with genetic mutations and animal models, the research aims to uncover the mechanisms behind thyroid hormone deficiency and its impact on various bodily functions. Patients may gain insights into thyroid-related conditions and potential new treatment approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of thyroid hormone deficiencies, benefiting patients with related conditions.
How similar studies have gone: Previous research has shown promising results in understanding thyroid hormone deficiencies, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Young, Kathy Crystal — University of Michigan at Ann Arbor
- Study coordinator: Young, Kathy Crystal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.