Understanding how the body adapts to low oxygen levels over time
Official title: Molecular insights into acute and chronic hypoxia tolerance: Investigating mechanisms of short-term plasticity and long-term genetic adaptation
Funded at Kent State University · NIH-10795138 · Data updated 2026-11-12
This study looks at how people’s bodies react to low oxygen levels, especially those who live in high places all the time and those who visit for a short time, to understand why some people adapt better than others.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kent State University NIH-funded |
| Lab location | 1 site (Kent, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $456,000 |
| NIH project number | 1R15GM152940-01 |
| Project ID | NIH-10795138 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who frequently experience low oxygen levels, such as residents of high-altitude areas or those with respiratory disorders.
✕Less likely to help
Patients who do not experience hypoxia or have no related health conditions may not benefit from this research.
What this research studies
This research investigates how the body responds to low oxygen levels, both in the short term and long term. It focuses on populations living at high altitudes who experience chronic hypoxia and those who visit high altitudes for short periods facing acute hypoxia. By examining genetic variations and physiological changes, the study aims to uncover the mechanisms that allow some individuals to adapt better to these conditions. This could involve analyzing how often and how long individuals are exposed to low oxygen levels and how their bodies adjust accordingly.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to oxygen deprivation, benefiting patients with respiratory issues or those living at high altitudes.
How similar studies have gone: Previous research has shown promising results in understanding genetic adaptations to hypoxia, but this specific investigation into acute responses is relatively novel.
Where this research is happening
-
Kent State University
Kent, United States Active
Researchers
- Principal investigator: Lamichhaney, Sangeet — Kent State University
- Study coordinator: Lamichhaney, Sangeet
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.