Understanding how the body adapts to low oxygen levels
Plasticity and Nitric Oxide Signaling: Identifying the Novel Adaptive Mechanisms Associated with Response to Hypoxia
['FUNDING_OTHER'] · UNIVERSITY OF KANSAS LAWRENCE · NIH-11194537
This study looks at how our bodies handle low oxygen levels and how a substance called nitric oxide helps improve oxygen use and blood flow, using zebrafish to learn more about the genes and processes that help living things adapt to these conditions, which could be important for understanding heart and blood vessel diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS LAWRENCE (nih funded) |
| Locations | 1 site (LAWRENCE, UNITED STATES) |
| Trial ID | NIH-11194537 on ClinicalTrials.gov |
What this research studies
This research investigates how the body responds to low oxygen environments, focusing on the role of nitric oxide in enhancing oxygen uptake and blood flow. By studying zebrafish, the researchers aim to identify the genetic and biochemical pathways that help organisms adapt to hypoxia, which can be crucial for understanding cardiovascular diseases. The study will explore how these adaptive mechanisms work at both the cellular and systemic levels, providing insights into how the body maintains balance in oxygen availability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect oxygen levels in the body, such as certain cardiovascular diseases or those living at high altitudes.
Not a fit: Patients who do not have any cardiovascular issues or who are not affected by oxygen deprivation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cardiovascular diseases related to oxygen deprivation.
How similar studies have performed: Previous research has shown success in understanding adaptive mechanisms to hypoxia, but this specific approach using zebrafish is relatively novel.
Where this research is happening
LAWRENCE, UNITED STATES
- UNIVERSITY OF KANSAS LAWRENCE — LAWRENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRAHAM, ALLIE M — UNIVERSITY OF KANSAS LAWRENCE
- Study coordinator: GRAHAM, ALLIE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.