Understanding how the body absorbs iron from food in different conditions.
Mechanisms of Intestinal Heme-iron Absorption in Rat Models of Iron Deficiency and Iron Overload
This study is looking at how our bodies take in heme iron from food, especially for people dealing with low iron levels or too much iron, to help improve treatments for conditions like anemia and hemochromatosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11081686 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of how the body absorbs heme iron, a type of iron found in food, particularly in the context of iron deficiency and overload. Using a rat model, the study aims to uncover the biological processes involved in iron absorption, which could lead to better understanding and treatment of conditions like anemia and hereditary hemochromatosis. The research focuses on how the body regulates iron levels through intestinal absorption, which is crucial for maintaining overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for iron deficiency or overload, such as children, pregnant women, and those with hereditary hemochromatosis.
Not a fit: Patients who do not have issues related to iron absorption or regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for iron deficiency and overload, benefiting patients with anemia and related conditions.
How similar studies have performed: Previous research has shown success in understanding iron absorption mechanisms in animal models, but this specific approach using rats for heme iron absorption is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Collins, James F. — University of Florida
- Study coordinator: Collins, James F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.