Understanding how the bladder senses fullness
How is Fullness Sensed in the Urinary Bladder?
This study is looking at how the bladder tells the brain when it's full, which could help improve treatments for bladder problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10862749 on NIH RePORTER |
What this research studies
This research investigates the physiological mechanisms behind how the urinary bladder communicates its fullness to the brain. By exploring the local mechanical changes in the bladder wall during filling, the study aims to uncover how these changes trigger nerve activity that signals the need to void. The approach involves examining the role of micromotions and localized tension in the bladder wall, which are believed to be critical for sensing fullness. This fundamental understanding could lead to better treatments for bladder dysfunctions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing urinary bladder dysfunction or related disorders.
Not a fit: Patients with normal bladder function or those not experiencing any urinary issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals suffering from bladder dysfunctions.
How similar studies have performed: While the mechanisms of bladder fullness sensing are not fully understood, this research approach is novel and aims to fill a significant gap in current knowledge.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Herrera, Gerald M. — University of Vermont & St Agric College
- Study coordinator: Herrera, Gerald M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.