Understanding how the bladder lining helps protect kidneys during urinary blockages
Novel roles for urothelium during urinary tract obstruction
['FUNDING_R01'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-10814218
This study is looking at how the bladder lining helps protect kids' kidneys from damage when there are blockages in the urinary tract, and it hopes to find new treatments that can make this protection even better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-10814218 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the urothelium, the bladder lining, in protecting the kidneys from damage caused by urinary tract obstructions, which are a common cause of chronic kidney disease in children. The researchers will explore how the urothelium undergoes changes in response to these obstructions and how these changes can help prevent kidney injury. By studying both congenital and acquired urinary tract obstructions in animal models, they aim to identify potential pharmaceutical treatments that could enhance the protective functions of the urothelium. This work could lead to new strategies for preventing kidney damage in affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are experiencing urinary tract obstructions.
Not a fit: Patients with urinary tract issues unrelated to obstruction or those over 11 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent kidney damage in children with urinary tract obstructions.
How similar studies have performed: Previous research has shown promising results in understanding the protective roles of urothelial cells, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BECKNELL, BRIAN — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: BECKNELL, BRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.