Understanding how the biliary system develops and functions
Inside-out construction of the biliary system
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10762472
This study looks at how the bile ducts in the liver form and work, especially when there are problems that can cause serious health issues, and it aims to find ways to help the liver heal better and tackle long-term liver diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10762472 on ClinicalTrials.gov |
What this research studies
This research investigates the formation and function of the intrahepatic biliary tree, which is crucial for draining bile from the liver. It explores how congenital or acquired abnormalities in bile duct formation can lead to severe health issues. The study focuses on the self-organizing process of liver cells that develop into a functional biliary network without cell division. By understanding the mechanisms behind biliary morphogenesis, the research aims to improve liver regeneration and address chronic liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with congenital biliary abnormalities or chronic liver diseases.
Not a fit: Patients with fully functional biliary systems and no history of liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver diseases and congenital abnormalities affecting the biliary system.
How similar studies have performed: Previous research has shown promising results in understanding liver regeneration and biliary morphogenesis, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCCLATCHEY, ANDREA I — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: MCCLATCHEY, ANDREA I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.