Understanding how the bc1 complex binds substrates
Regulation of Substrate Binding in the bc1 Complex
['FUNDING_R15'] · JAMES MADISON UNIVERSITY · NIH-10203271
This study is looking at an important enzyme that helps our cells produce energy and can create harmful substances, to see how different factors affect its function, which could lead to better treatments for diseases like cancer.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JAMES MADISON UNIVERSITY (nih funded) |
| Locations | 1 site (HARRISONBURG, UNITED STATES) |
| Trial ID | NIH-10203271 on ClinicalTrials.gov |
What this research studies
This research investigates the bc1 complex, a crucial enzyme in cellular respiration that produces reactive oxygen species. The team will use both computational models and experimental techniques to explore how different factors, such as lipid composition and specific protein modifications, affect the binding of substrates to this enzyme. By examining these mechanisms, the research aims to uncover new insights into the regulation of the bc1 complex and its role in various diseases, including cancer. Patients may benefit from a better understanding of how this enzyme functions and its implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction or malignancies, particularly breast cancer.
Not a fit: Patients with conditions unrelated to mitochondrial function or those not affected by the bc1 complex may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to the bc1 complex, including certain cancers.
How similar studies have performed: While the specific mechanisms being investigated are novel, similar approaches have shown promise in understanding enzyme regulation in other contexts.
Where this research is happening
HARRISONBURG, UNITED STATES
- JAMES MADISON UNIVERSITY — HARRISONBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOKHAN, OLEKSANDR — JAMES MADISON UNIVERSITY
- Study coordinator: KOKHAN, OLEKSANDR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer