Understanding how the bc1 complex binds substrates
Official title: Regulation of Substrate Binding in the bc1 Complex
Funded at James Madison University · NIH-10203271 · Data updated 2026-11-12
This study is looking at an important enzyme that helps our cells produce energy and can create harmful substances, to see how different factors affect its function, which could lead to better treatments for diseases like cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James Madison University NIH-funded |
| Lab location | 1 site (Harrisonburg, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2021 |
| Award (this year) | $402,105 |
| NIH project number | 1R15GM141975-01 |
| Project ID | NIH-10203271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction or malignancies, particularly breast cancer.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or those not affected by the bc1 complex may not benefit from this research.
What this research studies
This research investigates the bc1 complex, a crucial enzyme in cellular respiration that produces reactive oxygen species. The team will use both computational models and experimental techniques to explore how different factors, such as lipid composition and specific protein modifications, affect the binding of substrates to this enzyme. By examining these mechanisms, the research aims to uncover new insights into the regulation of the bc1 complex and its role in various diseases, including cancer. Patients may benefit from a better understanding of how this enzyme functions and its implications for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to the bc1 complex, including certain cancers.
How similar studies have gone: While the specific mechanisms being investigated are novel, similar approaches have shown promise in understanding enzyme regulation in other contexts.
Where this research is happening
-
James Madison University
Harrisonburg, United States Active
Researchers
- Principal investigator: Kokhan, Oleksandr — James Madison University
- Study coordinator: Kokhan, Oleksandr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.