Understanding how the BAP1/ASXL3 complex affects gene regulation and development
Role of BAP1/ASXL3 complex in transcriptional regulation and development
['FUNDING_OTHER'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10870191
This study is looking at how a specific protein complex affects gene activity, which could help us understand and find new treatments for developmental disorders and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10870191 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the BAP1/ASXL3 complex in regulating gene expression and its implications for developmental disorders and cancers. By studying how this complex interacts with chromatin and influences transcriptional repression, the research aims to uncover new biomarkers that could lead to innovative treatments. The approach involves analyzing the molecular mechanisms behind gene activation and silencing, particularly focusing on the histone modification known as H2AK119ub. This could provide insights into the genetic alterations that contribute to various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with developmental disorders, neuronal disorders, or cancers that may be linked to mutations in the BAP1 complex.
Not a fit: Patients with conditions unrelated to epigenetic dysregulation or those without genetic mutations in the BAP1 complex may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of new therapeutic targets and prognostic markers for developmental disorders and cancers.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic factors in disease, indicating that this approach could yield significant insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, LU — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: WANG, LU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Disease, Disorder