Understanding how the BAF complex regulates immune responses in germinal centers
Official title: Regulation of germinal center homeostasis by the BAF complex
Funded at Northwestern University at Chicago · NIH-11020143 · Data updated 2026-11-12
This study is looking at how a group of proteins helps keep certain immune cells healthy so they can make strong antibodies, which is important for fighting infections and diseases like lymphoma, and it aims to find ways to improve our immune responses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | November 12, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $606,501 |
| NIH project number | 1R01AI187142-01 |
| Project ID | NIH-11020143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting B cell function or those at risk for Diffuse Large B-Cell Lymphoma.
✕Less likely to help
Patients with non-immune related conditions or those not experiencing issues with B cell function may not benefit from this research.
What this research studies
This research investigates the role of the BAF complex in maintaining the health and function of germinal centers, which are crucial for generating effective immune responses. By examining how B cells differentiate and respond within these centers, the study aims to uncover the mechanisms that lead to high-quality antibody production. The researchers will utilize advanced techniques to analyze the genetic and epigenetic changes that occur in B cells, particularly focusing on specific mutations associated with lymphoma. This work could provide insights into how to enhance immune responses or address immune-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to immune dysfunction, including certain types of lymphoma.
How similar studies have gone: Previous research has shown promising results in understanding the role of chromatin remodeling in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Shukla, Vipul — Northwestern University at Chicago
- Study coordinator: Shukla, Vipul
Related research
Other NIH-funded projects on the same topics.
-
High-intensity exercise as a treatment for Parkinson's disease
This study is looking at whether doing high-intensity endurance exercise can help people who have just been diagnosed with Parkinson's disease feel better and slow down their symptoms, especially since current medications don't always do the trick.
-
Software to quickly assess organ dose after radionuclide exposure
This study is creating a helpful software tool that quickly calculates how much radiation your organs absorb after you've taken certain radioactive substances, so you can get better care and treatment based on your individual needs.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for better ways to improve your care and treatment, so you can get more personalized options that work best for you.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for new ways to improve care and treatment for patients, and if you join, you might help test some exciting new methods that could lead to better health for everyone.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for ways to improve care and treatment for patients like you, by trying out new methods that could help manage your health better.
-
Investigating core biological processes
This study is all about exploring important biological processes that affect our health, and it invites patients to help discover new ways to improve care for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.