Understanding how the BAF complex regulates immune responses in germinal centers
Regulation of germinal center homeostasis by the BAF complex
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11020143
This study is looking at how a group of proteins helps keep certain immune cells healthy so they can make strong antibodies, which is important for fighting infections and diseases like lymphoma, and it aims to find ways to improve our immune responses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11020143 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the BAF complex in maintaining the health and function of germinal centers, which are crucial for generating effective immune responses. By examining how B cells differentiate and respond within these centers, the study aims to uncover the mechanisms that lead to high-quality antibody production. The researchers will utilize advanced techniques to analyze the genetic and epigenetic changes that occur in B cells, particularly focusing on specific mutations associated with lymphoma. This work could provide insights into how to enhance immune responses or address immune-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting B cell function or those at risk for Diffuse Large B-Cell Lymphoma.
Not a fit: Patients with non-immune related conditions or those not experiencing issues with B cell function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to immune dysfunction, including certain types of lymphoma.
How similar studies have performed: Previous research has shown promising results in understanding the role of chromatin remodeling in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHUKLA, VIPUL — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: SHUKLA, VIPUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.