Understanding how the bacteria causing tularemia infects the body
Molecular elucidation of the Francisella tularensis virulence mechanism
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11074553
This study is looking at how the bacteria that cause tularemia can make you sick and avoid your body's defenses, with the hope of finding better ways to prevent or treat infections for people who might be at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11074553 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which Francisella tularensis, the bacterium responsible for tularemia, causes disease. It focuses on specific proteins and genetic factors that enable the bacteria to infect host cells and evade the immune response. By using advanced techniques like cryo-electron microscopy, the study aims to elucidate the interactions between bacterial proteins and host cell components. This understanding could lead to new strategies for preventing or treating infections caused by this highly infectious pathogen.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals at risk of exposure to Francisella tularensis, such as those in certain occupational settings or geographic areas.
Not a fit: Patients who are not at risk of exposure to tularemia or those with existing immunity to the bacterium may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments or vaccines against tularemia, potentially saving lives during outbreaks.
How similar studies have performed: Previous research has shown success in understanding bacterial virulence mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHUMACHER, MARIA — DUKE UNIVERSITY
- Study coordinator: SCHUMACHER, MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.