Understanding how the area around a tumor affects colorectal cancer growth
A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancer
This project aims to create a special platform to better understand how the environment surrounding a tumor contributes to the development of colorectal cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11127426 on NIH RePORTER |
What this research studies
We are developing an advanced material, called a 4D-tunable hydrogel, that can mimic the complex environment around a tumor in the colon. This model will help us explore how physical and chemical changes in this environment, alongside genetic factors, influence how polyps turn into colorectal cancer. By understanding these interactions, we hope to uncover new insights into how this common cancer begins and progresses. This work brings together experts in materials science, engineering, and cancer biology to build a more accurate model of the colon's architecture.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients at this stage, but future clinical applications would target individuals at risk for or diagnosed with colorectal cancer.
Not a fit: Patients not affected by colorectal cancer or those seeking immediate treatment options would not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of colorectal cancer origins, potentially guiding the development of new ways to prevent or treat the disease.
How similar studies have performed: While the genetics of colon cancer are well-known, less is understood about the physical and chemical properties of the tumor microenvironment, making this approach novel in its focus on a 4D-tunable hydrogel platform.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Allbritton, Nancy L. — University of Washington
- Study coordinator: Allbritton, Nancy L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.