Understanding how the antidepressant Duloxetine can harm the liver
Mechanisms of Liver Toxicity of Anit-Depressant Duloxetine
This study is looking into how the antidepressant Duloxetine might affect liver health, especially for those who take it, to help find ways to prevent any potential liver damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10539288 on NIH RePORTER |
What this research studies
This research investigates the liver toxicity associated with the antidepressant Duloxetine, which is commonly prescribed but can lead to liver damage in some patients. The study aims to uncover the mechanisms behind this toxicity by examining how Duloxetine affects the balance of certain lipids in the liver. Researchers will use various experimental approaches, including pharmacological and genetic modifications, to assess the impact of Duloxetine on liver health. By identifying the pathways involved, the research seeks to develop strategies to predict and prevent liver injury in patients taking this medication.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are currently prescribed Duloxetine or have experienced liver issues while on this medication.
Not a fit: Patients who are not taking Duloxetine or do not have any liver-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer use of Duloxetine and improved management of patients at risk for liver damage.
How similar studies have performed: Previous research has shown that understanding drug-induced liver injury can lead to better patient outcomes, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Li, Feng — Baylor College of Medicine
- Study coordinator: Li, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.