Understanding how the androgen receptor works in the body
Biochemical, structural and molecular dissection of androgen receptor transcriptional activity
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-10917134
This study is looking at a protein called the androgen receptor, which plays an important role in male development and is connected to health issues like prostate cancer and hair loss, to help us understand how it works and how we might improve treatments for these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10917134 on ClinicalTrials.gov |
What this research studies
This research investigates the androgen receptor (AR), a key protein that influences male development and is linked to various health issues like prostate cancer and hair loss. By using advanced techniques such as electron microscopy and x-ray crystallography, the study aims to uncover how AR is activated and regulated by different molecules. The findings will be tested in cell lines that depend on AR to understand how these interactions affect cell behavior and growth. This research could lead to new insights into treating conditions related to AR dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions like metastatic prostate cancer, androgenetic alopecia, or androgen-insensitivity syndrome.
Not a fit: Patients with conditions unrelated to androgen receptor activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions associated with abnormal androgen receptor activity.
How similar studies have performed: Previous research has shown promising results in understanding androgen receptor mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WASMUTH, ELIZABETH VICTORINA — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: WASMUTH, ELIZABETH VICTORINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Androgen-Insensitivity Syndrome