Understanding how the amygdala affects opioid relapse in patients with chronic pain
Amygdala kappa opioid system involvement in opioid relapse in pain states
This study is looking at how the brain's response to pain and stress can affect people with chronic pain who are trying to avoid going back to using opioids, and it hopes to find new ways to help them manage their pain and emotions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11049108 on NIH RePORTER |
What this research studies
This research investigates the role of the amygdala and its kappa opioid system in the context of opioid relapse among individuals suffering from chronic pain. It aims to understand how chronic opioid use alters brain function and contributes to negative emotional states, which can lead to increased drug-seeking behavior. By examining the interactions between pain, stress, and addiction, the study seeks to identify potential targets for therapeutic intervention. Patients may be involved in assessments that explore their pain experiences and opioid use patterns.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic pain who have a history of opioid use and are at risk for relapse.
Not a fit: Patients who do not have chronic pain or who have not used opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic pain patients struggling with opioid addiction.
How similar studies have performed: Previous research has shown promising results in understanding the brain's role in addiction and pain, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cahill, Catherine M — University of California Los Angeles
- Study coordinator: Cahill, Catherine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.