Understanding how the amniotic membrane develops during pregnancy
Molecular regulators of human amniogenesis
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11180341
This study is looking at how the protective amniotic membrane forms around a developing baby and aims to understand what helps these important cells grow, which could lead to better treatments for pregnancy issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11180341 on ClinicalTrials.gov |
What this research studies
This research investigates the process of amniogenesis, which is the formation of the amniotic membrane that protects the developing embryo. Using advanced 3D cell culture models, the study examines how specific signals and mechanical cues influence the development of amniotic cells from pluripotent stem cells. By analyzing the molecular mechanisms involved, the research aims to uncover the factors that drive the differentiation of these cells, which is crucial for a healthy pregnancy. Patients may benefit from insights gained that could lead to improved treatments for pregnancy-related complications.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing complications during pregnancy or those with conditions affecting fetal development.
Not a fit: Patients who are not pregnant or those with unrelated health conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of pregnancy and lead to better management of conditions that affect fetal development.
How similar studies have performed: Previous research has shown promising results in understanding cell differentiation processes, making this approach both innovative and grounded in established science.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TANIGUCHI, KENICHIRO — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: TANIGUCHI, KENICHIRO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.