Understanding how the aging brain works in marmosets
Toward developing a navigation model of the aging brain in the marmoset
This study looks at a part of the brain called the entorhinal cortex in marmosets to understand why it gets damaged early in Alzheimer's disease, which could help find new ways to treat the condition and learn more about how it affects memory.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11135740 on NIH RePORTER |
What this research studies
This research investigates the entorhinal cortex in marmosets, which is crucial for memory and is affected early in Alzheimer's disease. By studying the brain's structure and function in these animals, researchers aim to uncover why certain areas are more vulnerable to degeneration. The findings could help identify new targets for treatment and improve our understanding of Alzheimer's disease. The approach involves detailed physiological studies to compare the marmoset brain with other animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those experiencing early symptoms of memory loss.
Not a fit: Patients with advanced Alzheimer's disease or those not exhibiting any cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease and potential therapeutic strategies for patients.
How similar studies have performed: While studies on rodent models have shown success, this research is novel as it focuses on the marmoset, which has not been extensively studied in this context.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Nandy, Anirvan S. — Yale University
- Study coordinator: Nandy, Anirvan S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.