Understanding how the aging brain works in marmosets
Official title: Toward developing a navigation model of the aging brain in the marmoset
Funded at Yale University · NIH-11135740 · Data updated 2026-11-12
This study looks at a part of the brain called the entorhinal cortex in marmosets to understand why it gets damaged early in Alzheimer's disease, which could help find new ways to treat the condition and learn more about how it affects memory.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $461,146 |
| NIH project number | 1R21AG088866-01A1 |
| Project ID | NIH-11135740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease or those experiencing early symptoms of memory loss.
✕Less likely to help
Patients with advanced Alzheimer's disease or those not exhibiting any cognitive decline may not benefit from this research.
What this research studies
This research investigates the entorhinal cortex in marmosets, which is crucial for memory and is affected early in Alzheimer's disease. By studying the brain's structure and function in these animals, researchers aim to uncover why certain areas are more vulnerable to degeneration. The findings could help identify new targets for treatment and improve our understanding of Alzheimer's disease. The approach involves detailed physiological studies to compare the marmoset brain with other animal models.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease and potential therapeutic strategies for patients.
How similar studies have gone: While studies on rodent models have shown success, this research is novel as it focuses on the marmoset, which has not been extensively studied in this context.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Nandy, Anirvan S. — Yale University
- Study coordinator: Nandy, Anirvan S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.