Understanding how the aging brain changes after a type of stroke called intracerebral hemorrhage
Official title: Quantitative proteomic analysis of the aging brain after intracerebral hemorrhage
Funded at Augusta University · NIH-10708753 · Data updated 2026-11-12
This study is looking at how the aging brain changes after a serious stroke called intracerebral hemorrhage, to help us understand why older adults may struggle more with recovery, and it aims to find better treatment options for them.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $77,000 |
| NIH project number | 5R03AG077460-02 |
| Project ID | NIH-10708753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals who have experienced an intracerebral hemorrhage.
✕Less likely to help
Patients who are younger or have not experienced an intracerebral hemorrhage may not benefit from this research.
What this research studies
This research investigates the molecular changes that occur in the aging brain following an intracerebral hemorrhage (ICH), a severe type of stroke. By using advanced techniques like mass spectrometry, the study aims to identify changes in proteins that could help explain why older adults are more affected by ICH. The research will focus on specific brain cells involved in damage and repair processes, providing insights that could lead to better treatment options for elderly patients. Ultimately, this work seeks to fill a critical gap in understanding how age influences recovery from this condition.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving recovery and neurological outcomes in elderly patients who suffer from intracerebral hemorrhage.
How similar studies have gone: While research on stroke and aging is ongoing, this specific proteomic approach to understanding ICH in the elderly is relatively novel and has not been extensively tested.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Sukumari-Ramesh, Sangeetha — Augusta University
- Study coordinator: Sukumari-Ramesh, Sangeetha
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
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-
Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
-
Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
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Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
-
Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.