Understanding how the actin cytoskeleton works in cells
Structure and functions of the actin cytoskeleton
This study is looking at a part of our cells called the actin cytoskeleton, which helps cells move and shape themselves, to better understand how problems with it might be linked to diseases like cancer and brain disorders, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10886702 on NIH RePORTER |
What this research studies
This research investigates the structure and functions of the actin cytoskeleton, a crucial component of cells that influences their movement, shape, and interactions. By using advanced imaging techniques, specifically platinum replica electron microscopy, the research aims to visualize the actin cytoskeleton at a detailed level, which is essential for understanding its role in various diseases such as cancer and neurodegenerative disorders. The findings could provide insights into how disruptions in the actin cytoskeleton contribute to these conditions, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers, neurodegenerative disorders, or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to the actin cytoskeleton or those not experiencing significant cellular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases linked to abnormalities in the actin cytoskeleton.
How similar studies have performed: Previous research has shown promising results in understanding cellular structures and their implications in diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Svitkina, Tatyana — University of Pennsylvania
- Study coordinator: Svitkina, Tatyana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.