Understanding how the 3D structure of the human genome affects brain development and disorders.
Official title: Investigating the role of human-specific 3D genome conformation in the context of brain development and disease
Funded at Oregon Health & Science University · NIH-11022498 · Data updated 2026-11-12
This study is looking at how the 3D structure of our genes affects brain development and conditions like autism, and it hopes to find new ways to help people with these challenges by examining brain cells from humans and other primates.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $800,485 |
| NIH project number | 1R01MH138495-01 |
| Project ID | NIH-11022498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
✕Less likely to help
Patients who are older than 11 years or do not have neurodevelopmental disorders may not receive direct benefits from this research.
What this research studies
This research investigates the unique 3D organization of the human genome and its role in brain development and neurodevelopmental disorders like autism. By analyzing brain cells from humans and other primates, the study aims to identify specific genomic features that contribute to human brain complexity and vulnerability to conditions such as autism. The approach involves advanced genomic techniques to map and understand how these structures influence gene expression and brain function. Patients may benefit from insights that could lead to new therapeutic strategies for neurodevelopmental disorders.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and treatments for neurodevelopmental disorders, particularly autism.
How similar studies have gone: Previous research has shown promising results in understanding genome conformation and its implications for brain disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Carbone, Lucia — Oregon Health & Science University
- Study coordinator: Carbone, Lucia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.