Understanding how the 3D structure of the genome affects gene expression
Multimodal Analysis of the Genome Architecture Using Expansion Microscopy
This study is exploring how the way our genes are organized in three dimensions affects how they work, which is important for understanding growth and diseases, and it uses a new technique to look closely at these structures in individual cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11046506 on NIH RePORTER |
What this research studies
This research investigates the three-dimensional organization of the genome and its impact on gene expression, which is crucial for understanding biological processes related to development and disease. The approach involves developing a novel method that combines high-resolution imaging with genomic sequencing to analyze chromatin architecture at the single-cell level. By using expansion microscopy, the researchers aim to visualize the spatial structure of the genome while simultaneously profiling transcription and epigenetic marks. This comprehensive analysis could lead to new insights into how genome structure influences cellular functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by chromatin architecture and gene expression.
Not a fit: Patients with conditions unrelated to genetic regulation or chromatin structure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide groundbreaking insights into gene regulation and potentially lead to new therapeutic strategies for various diseases.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques to study chromatin structure, but this specific multimodal approach is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Giraldez, Antonio J — Yale University
- Study coordinator: Giraldez, Antonio J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.