Understanding how the 3D structure of the genome affects gene expression.
Nuclear Organization and Function
This study looks at how the way our genes are organized in three dimensions affects how they work, using fruit flies to help us learn more, and the hope is that what we find can help improve our understanding of gene-related diseases in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11006249 on NIH RePORTER |
What this research studies
This research investigates the relationship between the three-dimensional organization of the genome and gene expression, using Drosophila as a model organism. By analyzing the genome's structure at high resolution, the researchers aim to uncover how specific domains within the genome correlate with the transcriptional activity of genes. The study employs a multidisciplinary approach that includes genetics, epigenomics, and computational biology, with the goal of applying findings to human embryonic stem cells to better understand diseases. Patients may benefit from insights gained about gene regulation and its implications for various conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or cancers related to gene expression dysregulation.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by chromatin organization may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression in diseases, potentially improving treatment options.
How similar studies have performed: Previous research has shown success in understanding gene regulation through 3D genome organization, suggesting that this approach may yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Corces, Victor G. — Emory University
- Study coordinator: Corces, Victor G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.