Understanding how the 3D structure of DNA affects gene regulation and cancer.
Computational modeling of spatial genome organization and gene regulation
This study looks at how the way our DNA is organized in three dimensions affects how genes work, especially in cancer, and it aims to find new ways to help doctors understand and treat patients better based on these insights.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10689214 on NIH RePORTER |
What this research studies
This research investigates the three-dimensional organization of the genome and its impact on gene regulation, particularly in the context of cancer. By utilizing advanced techniques like high-throughput chromatin conformation capture (Hi-C), the study aims to develop computational methods that enhance our understanding of how DNA structure influences gene expression and stability. Patients may benefit from insights gained about the genetic mechanisms underlying their conditions, potentially leading to improved diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer, particularly those interested in the genetic factors influencing their disease.
Not a fit: Patients with non-malignant conditions or those not interested in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cancer mechanisms and developing targeted treatments.
How similar studies have performed: Other research has shown promising results in understanding genome organization and its implications for gene regulation, indicating that this approach has potential for success.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Ma, Wenxiu — University of California Riverside
- Study coordinator: Ma, Wenxiu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.