Understanding how the 3D structure of DNA affects gene function and development
Regulatory elements of replication timing and 3D genome organization
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-10862582
This study is looking at how the structure of our DNA affects how genes work, especially when cells change into different types, and it's for anyone interested in understanding how these processes might relate to diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10862582 on ClinicalTrials.gov |
What this research studies
This research investigates the three-dimensional (3D) organization of the genome and its role in regulating gene function, particularly during cell differentiation and development. By studying specific regulatory elements known as early replicating control elements (ERCEs) in human cells, the research aims to uncover how these elements interact with transcription factors to influence DNA replication timing and gene expression. The approach involves manipulating these elements in human differentiated cell types to observe changes in genome organization and gene activity, providing insights into the underlying mechanisms of various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene regulation and chromosomal abnormalities, particularly those affecting development.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating diseases linked to disruptions in gene regulation and genome organization.
How similar studies have performed: Other research has shown promising results in understanding genome organization and its implications for gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIVERA-MULIA, JUAN CARLOS — UNIVERSITY OF MINNESOTA
- Study coordinator: RIVERA-MULIA, JUAN CARLOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.