Understanding how the 3D structure of DNA affects B cell development and cancer.
Genome Architecture in Human Germinal Center B Cell Development, Malignancy, and Somatic Hypermutation
This study is looking at how the way our DNA is organized in B cells affects their development and can lead to certain blood cancers, using samples from tonsils and cancerous B cells to find out more about this connection.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10906189 on NIH RePORTER |
What this research studies
This research investigates the role of three-dimensional (3D) genome architecture in the development of B cells and the occurrence of B cell lymphomas. By analyzing human tonsil tissue and malignant B cell samples, the study aims to understand how the spatial organization of the genome influences somatic hypermutation, a process crucial for effective antibody production. The researchers will utilize a novel technique called Multiplexed Imaging of Nucleome Architectures (MINA) to explore the relationship between genome structure and the targeting of mutations that can lead to cancer. This approach seeks to uncover new insights into the mechanisms behind B cell malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with B cell lymphomas or those undergoing treatment for related conditions.
Not a fit: Patients with non-B cell malignancies or those without any B cell-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for B cell lymphomas and enhance vaccine efficacy.
How similar studies have performed: Previous research has shown promising results in understanding genome architecture's role in cancer, making this approach both innovative and grounded in existing scientific findings.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Schatz, David G. — Yale University
- Study coordinator: Schatz, David G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.