Understanding how THC affects movement control in the brain
Role of CB1R expressed in the prefrontal cortex in the control of locomotion
This study is looking at how THC, the main ingredient in cannabis, affects movement by exploring how certain brain receptors work, and it's for anyone interested in understanding how cannabis might change how we move.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10922675 on NIH RePORTER |
What this research studies
This research investigates the role of cannabinoid receptors in the prefrontal cortex and how they influence movement control, particularly in response to THC, the active compound in cannabis. By using a novel sensor to measure levels of a specific endocannabinoid, the study aims to uncover the neural mechanisms that THC activates, which may impair spontaneous locomotion. The research involves examining the interactions between different types of neurons in the brain to understand how THC alters movement behavior. This could provide insights into the broader effects of cannabis on motor functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who use cannabis and may experience changes in their movement or motor control.
Not a fit: Patients who do not use cannabis or have no interest in its effects on movement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of cannabis-related movement impairments.
How similar studies have performed: Previous research has shown that cannabinoids can affect movement, but this specific approach using novel sensors is relatively new and untested.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Stella, Nephi — University of Washington
- Study coordinator: Stella, Nephi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.