Understanding how THC affects cell signaling in the brain and blood
Impact of THC on Extracellular Vesicle Signaling
This study is looking at how THC, the active ingredient in cannabis, affects the brain and blood, especially when combined with nicotine, to help us understand its impact on health and identify markers related to its use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10982917 on NIH RePORTER |
What this research studies
This research investigates the impact of THC, the main psychoactive component of cannabis, on signaling mechanisms in the brain and blood. It focuses on how THC interacts with cannabinoid receptors found in various cell types that release extracellular vesicles. The study aims to identify biomarkers associated with THC use and examine how these effects may differ when nicotine is also present. By analyzing changes in extracellular vesicle signaling, the research seeks to provide insights into the biological effects of THC and its potential implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who use cannabis, particularly those who may also use nicotine.
Not a fit: Patients who do not use cannabis or nicotine may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how THC influences health and disease, potentially guiding safer cannabis use and therapeutic applications.
How similar studies have performed: While research on cannabinoids is ongoing, this specific investigation into THC's effects on extracellular vesicle signaling is relatively novel and has not been extensively tested.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Fowler, Christie D — University of California-Irvine
- Study coordinator: Fowler, Christie D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.